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电镜技术支撑发表的代表性成果(图文展示)

2025 脱氢枞酸通过双重激活 PPAR-γ 和 PPAR-α 改善高脂饮食诱导的胰岛素抵抗和肝脂肪变性

脱氢枞酸通过双重激活 PPAR-γ 和 PPAR-α 改善高脂饮食诱导的胰岛素抵抗和肝脂肪变性

通讯作者:中医药科学院谢治深教授

拍摄者:电镜中心工作人员

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2025 单核转录组学揭示烟碱诱导的腹侧被盖区转录变化及线粒体功能障碍

单核转录组学揭示烟碱诱导的腹侧被盖区转录变化及线粒体功能障碍

通讯作者:中国科技大学联合中国烟草生物效能实验室与中国科学院合肥研究所

拍摄者:电镜中心张彩丽老师

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1 A novel bifunctional peptide predicted to target neuropeptide Y4 and GLP-1 receptors alleviates cognitive deficits in 5 × FAD mice by modulating cGAS-STING-mediated neuroinflammation
2 First report of viable Toxoplasma gondii isolation from African lions (Panthera leo): Evidence for their status as intermediate hosts
3 Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway
4 Hederagenin improves Alzheimer's disease through PPARα/TFEB-mediated autophagy
5 Cholecystokinin and glucagon-like peptide-1 analogues regulate intestinal tight junction, inflammation, dopaminergic neurons and α-synuclein accumulation in the colon of two Parkinson's disease mouse models
6 Electroacupuncture Attenuates Learning and Memory Impairment via PI3K/Akt Pathway in an Amyloid β25-35-Induced Alzheimer's Disease Mouse Model
7 Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis
8 Proteomic analysis and experimental validation reveal the blood–brain barrier protective of Huanshaodan in the treatment of SAMP8 mouse model of Alzheimer’s disease
9 Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson's Disease Mouse Model
10 Neuroprotective Effects of a Cholecystokinin Analogue in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Parkinson's Disease Mouse Model